021-51111890
购物车（）
sales@molnova.cn
Alectinib hydrochloride
CAS No. 1256589-74-8
Alectinib hydrochloride ( CH5424802 hydrochloride;AF-802 hydrochloride;CH-5424802 hydrochloride )
产品货号. M11052 CAS No. 1256589-74-8
A potent, selective ALK inhibitor with IC50 of 1.9 nM; shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥413 | 有现货 |
|
| 25MG | ￥624 | 有现货 |
|
| 50MG | ￥794 | 有现货 |
|
| 100MG | ￥1320 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Alectinib hydrochloride
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A potent, selective ALK inhibitor with IC50 of 1.9 nM; shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM).
-
产品描述A potent, selective ALK inhibitor with IC50 of 1.9 nM; shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM); exhibits anti-proliferative activity against NPM-ALK-positive cellline KARPAS-299 with IC50 of 3 nM; also inhibits mutant ALK F1174L and R1275Q with IC50 of 1 nM and 3.5 nM respectively; orally active.Lung Cancer Approved
-
同义词CH5424802 hydrochloride;AF-802 hydrochloride;CH-5424802 hydrochloride
-
通路Angiogenesis
-
靶点ALK
-
受体ALK
-
研究领域Cancer
-
适应症Lung Cancer
化学信息
-
CAS Number1256589-74-8
-
分子量519.08
-
分子式C30H35ClN4O2
-
纯度>98% (HPLC)
-
溶解度DMSO: 6 mg/mL (Need ultrasonic or warming)
-
SMILESCCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C.Cl
-
化学全称5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-, hydrochloride (1:1)
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Kinoshita K, et al. Bioorg Med Chem. 2012 Feb 1;20(3):1271-80.
2. Sakamoto H, et al. Cancer Cell. 2011 May 17;19(5):679-90.
3. Kodama T, et al. Mol Cancer Ther. 2014 Dec;13(12):2910-8.
2. Sakamoto H, et al. Cancer Cell. 2011 May 17;19(5):679-90.
3. Kodama T, et al. Mol Cancer Ther. 2014 Dec;13(12):2910-8.
产品手册
关联产品
-
CEP-28122
A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
-
AP26113
AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay.
-
AZD3463
AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency.
